1. Quadriplegia - loss of function in arms and legs, usually caused by spinal cord lesion in the C3-T1 levels.
2. Rheumatic Heart Disease (Chronic) - a complication of rheumatic fever, scarring of the heart valves reduces heart efficiency.
3. Rheumatoid arthritis - inflammation of synovial joints with an autoimmune and systemic origin.
4. Sickle cell disease - hereditary blood disease that typically results in anemia and other complications.
5. Stroke (Cerebral Vascular Accident) - brain tissues are injured/destroyed when blood supply is cut off.